Mathematical Analysis utilizing biomechanics and basic physics can be used to determine the energy cost of various running factors.  When the energy cost is known and compared to empirical data the time penalty associated with these factors can be determined.  Running variables, combinations thereof, and their effect on performance that can be readily analyzed include:

Shoe weight | Summary | Analysis
Shoe cushioning
Over-stride/cadence  |  Summary
Excess body weight
Foot strike

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